Promethazine HCl and Codeine Phosphate Oral Remedy needs to be utilised with warning in patients with bone- marrow melancholy. Leukopenia and agranulocytosis are already documented, generally when promethazine has been Utilized in association with other recognized marrow-harmful agents.

If you're utilizing a liquid type, use a medication-measuring unit or spoon to cautiously evaluate the prescribed dose. Don't utilize a residence spoon because you may not get the proper dose. If your liquid variety is usually a suspension, shake the bottle effectively right before Every dose.

Lengthy-phrase use of promethazine/codeine may well have an impact on your ability to become pregnant or obtain a partner pregnant. Discuss with your Health care company For those who have any concerns.

Make certain you know how to consider this product or service and what other prescription drugs you'll want to steer clear of using with it. See also Drug Interactions area. Get professional medical enable instantly if any of such incredibly major Unwanted side effects happen: slow/shallow respiration, unusual lightheadedness, severe drowsiness/dizziness, issues waking up.

Promethazine Promethazine is usually a phenothiazine derivative, which differs structurally with the antipsychotic phenothiazines through the existence of a branched facet chain and no ring substitution.

It is actually soluble in water and freely soluble in alcohol. It's a molecular body weight of 320.88, a molecular formula of C17H20N2S•HCl, and the following structural method:

g., amiodarone, quinidine) may lead to a rise in codeine plasma concentrations as well as a minimize in Energetic metabolite morphine plasma concentration which could bring about an analgesic efficacy reduction or signs or symptoms of opioid website withdrawal.

The subsequent adverse reactions are already identified throughout scientific studies, while in the literature, or for the duration of post-acceptance usage of codeine and/or promethazine.

Neuroleptic malignant syndrome (NMS) which Actavis promethazine codeine can cause Dying. Tell you healthcare supplier without delay When you have any of the following indicators of NMS:

The majority of studies inspecting the usage of promethazine in pregnancy did not obtain an association with an elevated possibility of congenital anomalies. While in the handful of studies reporting an Affiliation, no steady sample of malformations was famous.

Administration of codeine can be accompanied by histamine launch and should be made use of with warning in atopic children.

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Codeine resembles morphine both structurally and pharmacologically, but its actions with the doses of codeine made use of therapeutically are milder, with much less sedation, respiratory melancholy and gastrointestinal, urinary, and pupillary outcomes. Codeine provides a rise in biliary tract Actavis promethazine codeine force, but fewer than morphine or meperidine. Codeine is much less constipating than morphine.

Tell your medical doctor In the event your cough will not get well in five times. Also, tell your medical doctor If the ailment receives even worse, or For those who have a headache that doesn't click here go away, fever, or rash. These could be indicators of a serious medical issue and should be checked by a health care provider.